How oral medicines differ Each oral medicine for ED has a slightly different chemical makeup. The information provided is for educational purposes only and is not intended to replace discussions with a healthcare provider. They include dutasteride Avodart, Jalyn and finasteride Propecia, Proscar. Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. They enhance the effects of a chemical the body makes that relaxes muscles in the penis, called nitric oxide. As with sildenafil, a high-fat meal or alcohol keep the body from absorbing it as quickly. This medicine works best when you take it on an empty stomach an hour before sex.The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 . CHOOSE BRAND-NAME VIAGRA. The original little blue pill prescribed by doctors for over 20 years. Clinically proven to treat men with erectile dysfunction (ED) Ongoing . Optum Store Sildenafil If you are experiencing the symptoms of erectile dysfunction (ED), you may have considered using Viagra or a similar ED medication as a possible .