As highlighted in the dapoxetine summary of product characteristics , antidepressants including SSRIs increased the risk of suicidal thinking and suicidality compared with placebo in short-term studies in children and young people with major depressive disorder and other psychiatric disorders. Dapoxetine is licensed for treating premature ejaculation in adult men aged 18 to 64 years. In 3 of the RCTs Buvat et al. There are limited data available on the safety and efficacy of dapoxetine ‘on demand’ for longer than 24 weeks. McMahon et al. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults who are aged over Dosage, administration, and formulation. Oral dapoxetine is indicated for the treatment of men. Dapoxetine is a short-acting selective serotonin-reuptake inhibitor (SSRI). The time to maximum plasma concentration is about 1 to 2 hours after intake. Plasma levels are . If a patient stops taking one of these drugs, he should wait for 14 days before taking dapoxetine. If a patient stops taking dapoxetine, he should wait for 7 days before .