These PDE5 inhibitors may cause headache, flushing, drop in blood pressure, or other adverse effects. Tadalafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus HIV. While each PDE5 inhibitor differs slightly, they’re very similar in treating erectile dysfunction. Yes, ED pills can cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache. Tadalafil may cause side effects.heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating. Common tadalafil side effects may include: headache; flushing (warmth, redness, or tingly feeling); nausea, upset stomach; stuffy nose; or. muscle pain, back pain, pain in your arms, legs, or back. This is not a complete list of side. SesameRX offers sildenafil and tadalafil—the generics of Viagra and Cialis—for just $5 with free four-day delivery. With Sesame, you can get virtual care and ED medications without breaking the bank. Cialis Daily (tadalafil): This low-dose Cialis works by increasing blood flow to the penis over time, making it easier to have an erection. Tadalafil is a medicine used to treat erectile dysfunction (ED, also called impotence) and problems with urination caused by an enlarged prostate (benign prostatic hypertrophy or BPH). It is sometimes known by its generic name tadalafil, and sometimes known by its trade name, Cialis. There are also other brands of this medicine available.